Director, Clinical Development (Clinical Science)

About Apogee Therapeutics

Founded in 2022, Apogee Therapeutics, Inc. (Ticker: APGE) is a well-funded, Nasdaq listed company that offers the opportunity to work in a fast-paced, highly dynamic environment. At Apogee, you can actively contribute to shaping the company culture, take on various roles and responsibilities, and grow professionally.

Apogee Therapeutics is a clinical-stage biotechnology company advancing novel biologics with potential for differentiated efficacy and dosing in the largest I&I markets, Apogee’s antibody programs are designed to overcome limitations of existing therapies by targeting well-established mechanisms of action and incorporating advanced antibody engineering to optimize half-life and other properties. Zumilokibart (APG777), the company’s most advanced program, is being initially developed for the treatment of atopic dermatitis (AD), which is the largest and one of the least penetrated I&I markets, as well as asthma. With four validated targets in its portfolio, Apogee is seeking to achieve best-in-class efficacy and dosing through monotherapies and combinations of its novel antibodies. Based on a broad pipeline and depth of leadership and expertise, the company believes it can deliver value and meaningful benefit to patients underserved by today’s standard of care.

We are a fast-paced company committed to building an exceptional culture, founded on our C.O.R.E. values: Caring, Original, Resilient and Egoless and a commitment to refusing to stop at “good enough”.

If this sounds like you, keep reading!

Role Summary

We are seeking an experienced non-MD Clinical Scientist. As a Director in Clinical Development, you will support the scientific planning and execution of one or more clinical trials in inflammation & immunology. This highly visible role involves co-leading studies with a Medical Director and working closely with cross-functional teams to design, implement, oversee and analyze clinical studies to advance the development of innovative therapies in our pipeline, including our lead dermatology clinical program. In this role you will contribute scientific expertise and strategic insights to ensure the successful progression of clinical programs.

Key Responsibilities

· Collaborate with cross-functional teams to develop clinical documents for trials with scientific rigor, such as protocol, investigator brochure, clinical study report, scientific publications/presentations, etc.

· Contribute scientific input and implementation into the study design and execution, including but not limited to selection of appropriate endpoints, patient populations, and study methodologies; site selection; investigator meetings; and study initiation activities

· Monitor the clinical trials for both quality and safety, ensuring adherence to protocols, timelines, and quality standards

· Analyze clinical trial data, interpret results, and provide scientific insights to guide decision-making

· Collaborate with data management and biostatistics to develop and validate data collection tools and ensure accurate and timely data capture

· Foster relationships with clinical investigators to gather insights, address scientific questions, and promote collaboration

· Stay current with scientific literature and advancements in immunology related to Apogee’s pipeline

· Collaborate with clinical operations, medical affairs, regulatory affairs, biostatistics, and other teams to ensure alignment of clinical strategies with overall program goals

Ideal Candidate

· Advanced degree in life science field (e.g., PhD, PharmD, or DVM)

· Must have 10 +years of experience in research, with 5+ years’ experience working in clinical development within the biotechnology or pharmaceutical industry preferred; focus on immunology and/or dermatology preferred

· Strong understanding of clinical trial design, execution, and data analysis

· Analytical mindset and ability to interpret complex scientific data

· Ability to manage multiple competing priorities with good planning, time management and prioritization skills

· Strong communication, technical writing, and presentation skills, with the ability to effectively convey scientific concepts to diverse audiences

· Proven ability to work in a cross-functional team environment

· Solid knowledge of Good Clinical Practice (GCP) and ethical guidelines governing clinical research

· Successfully exhibit Apogee’s C.O.R.E. values: Caring, Original, Resilient and Egoless

· Position requires approximately 35% travel including mandatory in-person attendance at Apogee All Hands meetings typically held twice per year. Travel is also required to attend key Phase 3 meetings, typically held at the Apogee San Francisco office. This position may also require US and international travel to clinical sites and/or medical conferences.

The anticipated salary range for candidates for this role will be $230,000-$260,000 / year. The final salary offered will depend on several factors, which may include, but is not limited to relevant years of experience, educational background, and geography.

What We Offer

• A great culture, grounded in our C.O.R.E. values: Caring, Original, Resilient and Egoless
• Opportunity to work in a fast-paced, highly dynamic environment where you help shape the culture and company, wear multiple hats, and learn quickly
• Market competitive compensation and benefits package, including base salary, performance bonus, equity grant opportunities, health, welfare & retirement benefits
• We provide competitive time off, including three weeks PTO, two one-week company-wide shutdowns a year and dedicated paid sick leave
• Commitment to growing you professionally and providing access to resources to further your development
• Apogee offers regular all team, in-person meetings to build relationships and problem solve

E-Verify Participation: As part of the I9 verification of authorization to work in the US, Apogee participates in E-Verify. To learn more about E-Verify please review this poster. Apogee Therapeutics is proud to be an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to sex, gender identity, sexual orientation, race, color, religion, national origin, disability, protected Veteran status, age, or any other characteristic protected by law. To review our privacy policy, click here It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.